Endocrine Abstracts

Case: We present an interesting case of pituitary hypophysitis following ipilimumab therapy. A 66 year old lady previously diagnosed with left ocular melanoma in 2006 was under oncology follow up, when routine surveillance scan showed recurrence in segment six of the liver. She underwent laparoscopy and was found to have multiple liver metastases following which she was commenced on ipilimumab. Four weeks after completing her second cycle of ipilimumab, she developed severe he...

Introduction: Hyponatraemia is a common cause of morbidity and mortality affecting 15–28% of inpatients. Tolvaptan is a competitive vasopressin 2 antagonist licensed to treat hyponatraemia secondary to the syndrome of inappropriate anti-diuretic hormone secretion (SIADH). There has been concern that tolvaptan treatment may lead to rapid overcorrection of sodium in a minority of patients, thus potentially leading to osmotic demyelination syndrome.Met...

Background: Ovarian granulosa cell tumours are rare, aggressive, hormonally active neoplasms.Case: A 16-year-old, nulliparous, Eastern European woman presented with a 9-month history of secondary amenorrhoea and a 2-month history of galactorrhoea. She denied headache or visual symptoms. Past medical history was unremarkable with menarche at age 14 and a previously normal menstrual cycle. She had never used hormonal contraception. Only medications were pa...

Objective: Chemerin a novel adipokine; affects the lipid and glucose homeostasis along with adipose tissue metabolism. Elevated levels of peptide have shown to be associated with disruption of normal insulin function and systemic inflammation, which also results in hyperglycemia in clinical diabetes. This study aims to identify whether chemerin in conjunction with TNFα and hsCRP can act as screening marker to identify subclinical diabetes.Methods: F...

Introduction: We present 3 cases of the same severe electrolyte imbalance presenting with acute neurological symptoms.Case descriptions: Case A, a 48 year old lady with severe CREST syndrome presented with prolonged vomiting and diarrhoea. Initial investigations showed: Sodium 141 mmol/l, Potassium 3.2 mmol/l, Creatinine 53 mmol/l, Glucose 4.3 mmol/l, Haemoglobin 13.9 g/dl, Albumin 38 g/l. 2 days after admission she developed seizures. Case B, a 75 year ...

Normal range glycemia towards higher side has been shown to have a higher risk than lower range of glycemia(1).People with impaired glucose tolerance (IGT) with better glycemic control would be an ideal step towards prevention of coronary heart disease CHD.Prevalence of undiagnosed diabetes remains high(2). Diagnosis of diabetes is made too late in too many patients. By the time diagnosis is made complications have already settled ...

BackgroundUse of Evolocumab as a monotherapy or in combination with other lipid lowering drugs reduces LDL-C by up to 60% in patients with or without familial hypercholesterolemia (FH), diabetes mellitus (DM), or coronary artery disease (CAD). Data regarding the efficacy of PCSK9 inhibitors in MENA populations is lacking.MethodRetrospective case review of all patients initiated on Evolocumab treatment at Impe...

Background: Hypercalcemia is a common clinical problem. Severe hypercalcemia or hypercalcemic crisis is an endocrine emergency and can be life threatening if left untreated. The condition has high mortality and requires immediate therapeutic interventions and diagnostics. A rapid rise to the calcium levels can result in the impaired function of organ systems including central nervous system. Hypercalcemia is mainly (more than 90%) caused by primary hyperparathyroidism or malig...

Chronic hypoparathyroidism (HypoPT) is a rare endocrine condition characterised by hypocalcaemia and deficient or absent parathyroid hormone. The recent European Society of Endocrinology Guidelines outline recommendations for treatment and monitoring of chronic HypoPT in adults. A Delphi panel was conducted to agree upon the characteristics that define ‘not adequately controlled on standard therapy’ where this relates to patients with chronic H...

Chronic hypoparathyroidism (HypoPT) is a rare endocrine condition characterised by hypocalcaemia and deficient or absent parathyroid hormone. The recent European Society of Endocrinology Guidelines outline recommendations for treatment and monitoring of chronic HypoPT in adults. A Delphi panel was conducted to agree upon the characteristics that define ‘not adequately controlled on standard therapy’ where this relates to patients with chronic H...